Karl Hoffmann may refer to:
Karl Hoffmann (architect) (1883–1951), German architect Karl Hoffmann (politician) (1820–1895), declined election to the Swiss Federal Council in 1881 Karl Hoffmann (naturalist) (1823–1859), German physician and naturalist Karl Hoffmann (linguist) (1915–1996), German linguist Karl Hoffmann (rower) (born 1906), German Olympic rower Karl Hoffmann (footballer) (1935–2020), German footballer Karl W. Hofmann (born 1961), former United States Ambassador to Togo
See also Carl Hoffman (born 1960), American travel and fiction writer Carl Henry Hoffman (1896–1980), U.S. Representative from Pennsylvania Carl Hoffmann (1885–1947), German cinematographer and film director Karl-Heinz Hoffmann (disambiguation)