HDC may refer to:
Computing Hyperdimensional computing, a computer science approach Handle of Device Context, part of the GDI API High-Definition Coding, an audio codec ; a Unix-like ATA device file
Law Holder in due course, in commercial law Home Detention Curfew, United Kingdom
Music Heavyweight Dub Champion, an American electronic group Herräng Dance Camp, Sweden
Organizations Halal Industry Development Corporation, Malaysia Health and Disability Commissioner, New Zealand Health Data Consortium, US Historic Districts Council, New York City, US Honeysuckle Development Corporation, NSW, Australia HDC Hyundai Development Company, South Korea
Transportation Haldia Dock Complex, of the Port of Kolkata, India Hammond Northshore Regional Airport (FAA LID code), Louisiana, US High Desert Corridor, proposed high-speed rail line in Southern California, US Hill descent control system, of an automobile
Other uses Histidine decarboxylase, an enzyme