Skosana is a surname. Notable people with the surname include:
Ben Skosana (1947–2014), South African politician Brian Skosana (born 1991), South African rugby union player Gijimani Skosana (born 1978), South African politician in the National Assembly since 2017 and former mayor of Dr JS Moroka James Skosana (1962–2021), South African politician in the National Assembly (2009–2018) and Mpumalanga Provincial Legislature Lwazi Skosana (born 1991), South African footballer Maki Skosana (–1985), South African woman who was burned to death
See also SS Skosana Nature Reserve, protected area in South Africa Minister of Police v Skosana, South African law case