The 1901 St. Xavier Musketeers football team was an American football team that represented St. Xavier College (later renamed Xavier University) as a member of the Interscholastic League during the 1901 college football season. The team compiled a 9–0 record, shut out five of nine opponents, and outscored all opponents by a total of 234 to 28. The team won the Interscholastic League championship and, with it, The Enquirer Pennant. Fullback Mark Mitchell was the team captain.
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