Guerini is an Italian surname. Notable people with the surname include:
Francesco Guerini (fl. 1740–1770), Italian violinist and composer Giuseppe Guerini (born 1970), Italian cyclist Lorenzo Guerini (born 1966), Italian politician Stanislas Guerini (born 1982), French politician Vincenzo Guerini (footballer) (born 1953), Italian football player and manager Vincenzo Guerini (athlete) (born 1950), Italian sprinter
See also Guerrini, another surname