Decaprenylphospho-beta-D-ribofuranose 2-oxidase (, decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase, Rv3790, DprE1) is an enzyme with systematic name trans,octacis-decaprenylphospho-beta-D-ribofuranose:FAD 2-oxidoreductase. This enzyme catalyses the following chemical reaction
trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2
This enzyme from the bacterium Mycobacterium smegmatis participates in epimerization of trans,octacis-decaprenylphospho-beta-D-ribofuranose to trans,octacis-decaprenylphospho-beta-D-arabinoofuranose.
Macozinone and quabodepistat are two investigational drugs that target DprE1.
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