CDP-paratose synthase (, rfbS (gene)) is an enzyme with systematic name CDP-alpha-D-paratose:NADP+ 4-oxidoreductase. This enzyme catalyses the following chemical reaction

CDP-alpha-D-paratose + NADP+ CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NADPH + H+

This enzyme participates in synthesis of paratose and tyvelose.

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