Potomac () may refer to:
Places in the United States Washington, D.C. area: The Potomac River, which flows through West Virginia, Maryland, Virginia, and Washington, D.C. The Potomac Highlands, a region of the Potomac River's watershed in West Virginia Patowmack Canal, also spelled Potomac, a series of five inoperative canals in Maryland and Virginia Potomac, Maryland, an unincorporated area in Montgomery County Potomac Airfield, a general aviation airport in Fort Washington, Maryland Potomac Park, Maryland, in Allegany County Potomac, Virginia, an extinct town formerly located in Arlington County
Other places in the U.S.: Potomac, Illinois, a village in Vermilion County Potomac, Montana, an unincorporated community in Missoula County Potomac, West Virginia, an unincorporated community
Companies Potomac Company, a former infrastructure company Epic Games, originally called Potomac Computer Systems, and American video game and software developer
Transportation Trains Potomac, a series of several former Amtrak passenger trains: Potomac (Amtrak train) Potomac Special Potomac Turbo
Vessels USS Potomac, one of six ships Potomac (tug), a Patapsco Class tug built for Vane Brothers Company
Other uses Patawomeck (or Potomac), a Native American tribe for whom the Potomac River was named Army of the Potomac, a major Union army during the American Civil War 1345 Potomac, an asteroid Potomac Horse Fever, a disease in horses Potomac Lake, an artificial lake in Gunnersbury Park, London University of the Potomac, a degree-granting college based in Washington, D.C. Potomak, a German record label