Osbaldeston is a surname. Notable people with the surname include:
Edward Osbaldeston, (c. 1560–1594), Catholic martyr George Osbaldeston, (1786–1866), cricketer Gordon Osbaldeston, (born 1930), Canadian civil servant Lambert Osbaldeston, (1594–1659), headmaster of Westminster School Nancy Osbaldeston (born 1989), English ballet dancer Richard Osbaldeston (Attorney General) (–1640), Anglo-Irish lawyer Richard Osbaldeston (1691–1764), Bishop of London Herbert Osbaldeston Duncan (1862–1945), English racing bicyclist, journalist, and pioneer of the British automobile industry William Osbaldeston (died 1707) (1631–1707), English politician
See also Osbaldeston baronets