45 Squadron or 45th Squadron may refer to:

No. 45 Squadron RAF, a unit of the United Kingdom Royal Air Force 45th Fighter Squadron, a soon to be activated unit of the United States Air Force 45th Reconnaissance Squadron, a unit of the United States Air Force 45th Airlift Squadron, a unit of the United States Air Force

See also 45th Division (disambiguation) 45th Brigade (disambiguation) 45th Regiment (disambiguation)