Francis Nicholls may refer to:
Frankie Knuckles (1955–2014), American DJ and record producer Francis T. Nicholls (1834–1912), two-term governor of Louisiana Francis Nicholls (artist) (1966–2020), New Zealand painter
See also Francis D. Nichol (1897–1966), Seventh-day Adventist Francis Nicolls (disambiguation), including Francis Nichols Francis Nicholson (disambiguation)